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- ÷ ETHICS, Page 70New Hope for Alzheimer's Victims
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- Even as Janet Adkins committed suicide, the short history
- of Alzheimer's disease seemed to be entering a new, more
- hopeful phase. First, it will soon be easier to identify
- Alzheimer's earlier and more accurately, thus easing the
- needless anxiety the elderly often feel at any lapse of memory
- or momentary confusion. (Doctors admit that their diagnoses of
- the disease are wrong about 30% of the time.) Second,
- Alzheimer's finally appears to be yielding to treatment, though
- a cure could be many years away.
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- Last week researchers at Abbott Laboratories near Chicago
- announced they had developed a new biochemical test that may
- prove to be highly reliable in detecting a collection of
- molecules, called Alzheimer's disease-associated proteins
- (ADAP), found in substantial quantities only in patients with
- the illness.
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- In an article published in the Journal of the American
- Medical Association, investigators from Abbott and seven other
- research centers in the U.S. and Europe reported the results
- of tests of 111 samples of brain tissue taken from people who
- had recently died. Some suffered from Alzheimer's, some had
- other neurological disorders, and the rest died from unrelated
- causes. Using a simple procedure involving common laboratory
- techniques, the scientists were able to identify 86% of the
- patients who had been stricken with Alzheimer's. The scientists
- expect that within two years they will be able to develop a
- similar test that would detect ADAP in spinal fluid taken from
- living patients.
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- Early diagnosis will be increasingly important as new
- treatments for Alzheimer's become available. Drug companies are
- testing more than 100 compounds that may at least relieve or
- delay the symptoms of the illness. Last week Warner-Lambert,
- a New Jersey pharmaceutical firm, applied for Government
- permission to market Cognex, a brand of tacrine, a drug that
- supposedly slows the loss of brain function in 40% of
- Alzheimer's patients who are given the medication. Such a drug,
- along with the new test to detect the disease, could conceivably
- add one or more productive years to the lives of Alzheimer's
- victims.
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